Radek jonak biography of albert
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Lorenzo Galluzzi
1 Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
2 INSERM, U1138, Paris, France
3 Gustave Roussy Cancer Campus, Villejuif, France
4 Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
Find articles by Lorenzo Galluzzi
Erika Vacchelli
1 Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
2 INSERM, U1138, Paris, France
3 Gustave Roussy Cancer Campus, Villejuif, France
Find articles by Erika Vacchelli
José-Manuel Bravo-San Pedro
1 Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
2 INSERM, U1138, Paris, France
3 Gustave Roussy Cancer Campus, Villejuif, France
Find articles by José-Manuel Bravo-San Pedro
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Abstract
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor expressed in many tissues, including skin, where it is essential for maintaining skin barrier permeability, regulating cell proliferation/differentiation, and modulating antioxidant and inflammatory responses upon ligand binding. Therefore, PPARγ activation has important implications for skin homeostasis. Over the past 20 years, with increasing interest in the role of PPARs in skin physiopathology, considerable effort has been devoted to the development of PPARγ ligands as a therapeutic option for skin inflammatory disorders. In addition, PPARγ also regulates sebocyte differentiation and lipid production, making it a potential target for inflammatory sebaceous disorders such as acne. A large number of studies suggest that PPARγ also acts as a skin tumor suppressor in both melanoma and non-melanoma skin cancers, but its role in tumorigenesis remains controversial. In this review, we have summ
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All Saints | Home
Out of the Ashes
Episode 12.01 (457)
Tue, Feb 03, 2009 (9.30)
1.298 million viewers (9th)
Produced bygd Bill Hughes
Written bygd Louise Crane-Bowes
Directed bygd Ian Gilmour
A boating accident in a remote river location has left kvartet people injured and stranded without medical help. slang för mikrofon and Steve are sent via chopper to attend to the casualties. Burns from an explosion in the boat's engine room plus the horrifying injuries of a man who fell into the boat's propeller will ensure they have their work cut out for them. And to add to the stress, one casualty fryst vatten pinned to the vägg of the sinking boat. Out of their bekvämlighet zone, the doctors will need to draw on all their strengths in order to triumph. And the presence of a feisty kvinnlig Paramedic who is in charge of the rescue will do little to calm the situation. The day's events will lead Mike to a decision that could change everything at All Saints.
Meanwhile, back in the ED, Frank has rallied his troops to prep